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Review
. 1992 Jan 6;6(2):731-6.
doi: 10.1096/fasebj.6.2.1537463.

Cytochrome P450 and the arachidonate cascade

J H Capdevila  1 , J R Falck, R W Estabrook
Affiliations
Review

Cytochrome P450 and the arachidonate cascade

J H Capdevila et al. FASEB J. .

Abstract

Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.

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