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Review
. 2004 Aug;69(8):855-60.
doi: 10.1023/b:biry.0000040216.18119.d5.

Regulation of gene expression via triple helical formations

Affiliations
Review

Regulation of gene expression via triple helical formations

V Karympalis et al. Biochemistry (Mosc). 2004 Aug.

Abstract

Triplex-forming oligonucleotides (TFOs) are a challenging and very promising subject in modern biochemistry and molecular genetics. Over the last decade, several studies have stated that TFOs: a) can bind to DNA in a sequence-specific manner; b) can provoke DNA repair and recombination in mammalian cells, and c) can be a very effective biological tool in embryonic and oncogenic research on gene expression pathways. Herein we review the basic modes in which TFOs exist, their gene-regulation properties, as well as the obstacles that should be overcome before they become useful in clinical practice (chemotherapy and/or gene therapy).

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