Regulation of gene expression via triple helical formations
- PMID: 15377264
- DOI: 10.1023/b:biry.0000040216.18119.d5
Regulation of gene expression via triple helical formations
Abstract
Triplex-forming oligonucleotides (TFOs) are a challenging and very promising subject in modern biochemistry and molecular genetics. Over the last decade, several studies have stated that TFOs: a) can bind to DNA in a sequence-specific manner; b) can provoke DNA repair and recombination in mammalian cells, and c) can be a very effective biological tool in embryonic and oncogenic research on gene expression pathways. Herein we review the basic modes in which TFOs exist, their gene-regulation properties, as well as the obstacles that should be overcome before they become useful in clinical practice (chemotherapy and/or gene therapy).
Copyright 2004 MAIK
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources