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. 2004 Oct;88(10):1263-5.
doi: 10.1136/bjo.2003.038471.

Effect of hypertension on foveolar choroidal haemodynamics

R M Niknam  1 , L S Schocket, T Metelitsina, J C DuPont, J E Grunwald
Affiliations

Effect of hypertension on foveolar choroidal haemodynamics

R M Niknam et al. Br J Ophthalmol. 2004 Oct.

Abstract

Aims: To assess the effect of systemic hypertension on the choroidal circulation in subjects with a normal eye examination.

Methods: Laser Doppler flowmetry was used to determine relative choroidal blood velocity (Ch(vel)), volume (Ch(vol)), and flow (Ch(flow)) in the centre of the fovea. Measurements were obtained in 15 eyes of 15 subjects with systemic hypertension. The mean average duration of hypertension was 11 (SD 6) years. Findings obtained in these patients were compared with those of 15 eyes of 15 age matched healthy controls. All subjects had normal eye examinations.

Results: No significant differences in Ch(vel), Ch(vol), and Ch(flow), were found between the subjects with and without systemic hypertension despite a 17% higher perfusion pressure (PP) in patients with hypertension. No significant correlation was found between mean arterial pressure or PP and the choroidal circulatory parameters. It was estimated that there is a 90% power to detect a 35% difference in Ch(flow) between the two groups.

Conclusion: Systemic hypertension does not seem to have a large effect on the choroidal circulation in hypertensive patients that are controlled by antihypertensive therapy. Further studies are needed to elucidate whether systemic hypertension has an effect on the choroidal circulation in patients with ocular diseases.

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Figures

Figure 1
Figure 1
Relative foveolar choroidal blood flow in arbitrary units (AU) for control and hypertensive (HTN) subjects. There is no statistically significant difference in average choroidal blood flow between both groups (non-paired Student’s t test; p = 0.6).
See this image and copyright information in PMC

References

    1. Epstein M, Sowers JR. Diabetes mellitus and hypertension (Review). Hypertension 1992;19:403–18. - PubMed
    1. Messerli FH, Grossman E, Michalewicz L. Combination therapy and target organ protection in hypertension and diabetes mellitus. (Review) Am J Hypertens 1997;10 (pt 2) :198S–201S. - PubMed
    1. Sperduto RD, Hillar R. Systemic hypertension and age related maculopathy in the Framingham Study. Arch Ophthalmol 1986;104:216–19. - PubMed
    1. Bischoff P, Flower RW. High blood presssure in choroidal arteries as a possible pathogenetic mechanism in senile macular degeneration. Am J Ophthalmol 1983;96:398–9. - PubMed
    1. Tso MO, Jampol LM. Pathophysiology of hypertensive retinopathy. Ophthalmology 1982;89:1132–45. - PubMed