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. 2004 Sep;87(2):197-201.
doi: 10.1023/B:BREA.0000041625.60280.4a.

Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma

Elisa Sensi  1 , Mariella Tancredi, Paolo Aretini, Giovanna Cipollini, Paola Collecchi, A Giuseppe Naccarato, Paolo Viacava, Generoso Bevilacqua, Maria A Caligo
Affiliations

Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma

Elisa Sensi et al. Breast Cancer Res Treat. 2004 Sep.

Abstract

GADD45 is a DNA damage responsive gene, induced following BRCA1 expression. Mutations at GADD45 might substitute for p53 alterations in hereditary breast tumours characterized by wild-type p53. We analyzed GADD45 alterations in 59 (15 BRCA-associated) familial breast carcinomas. No mutations were found. LOH at GADD45 locus was identified in 19/59 tumours. GADD45 does not appear to be a frequent mutational target in hereditary breast cancer.

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