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Review
. 2004 Sep 21;14(18):R759-61.
doi: 10.1016/j.cub.2004.09.014.

Heterochromatin: RNA points the way

James A Birchler  1 , Harsh H Kavi, Harvey R Fernandez
Affiliations
Free article
Review

Heterochromatin: RNA points the way

James A Birchler et al. Curr Biol. .
Free article

Abstract

Mutation of the multi-KH domain protein DPP1, which has single-stranded nucleic acid binding activity, suppresses heterochromatin-mediated silencing in Drosophila; it also disrupts the modification of histone H3 at lysine 9, and association of heterochromatin protein 1 on the heterochromatic regions, suggesting a role for DDP1 in heterochromatin formation.

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