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Comment
. 2004 Sep;11(9):1177-8.
doi: 10.1016/j.chembiol.2004.09.001.

A fine balancing act of type III polyketide synthase

Shiou-Chuan Tsai  1
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Comment

A fine balancing act of type III polyketide synthase

Shiou-Chuan Tsai. Chem Biol. 2004 Sep.

Abstract

In this issue of Chemistry & Biology, a novel Aldol-Switch mechanism is proposed for the biosynthesis of type III polyketides, which include many antioxidants found in colorful fruits. Based on structural and mutagenesis studies, the Aldol-Switch mechanism suggests that electronic effects balance between two competing cyclization specificities in Type III polyketide synthases. A novel hypothesis is also used to explain stilbenecarboxylate biosynthesis.

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