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. 2004 Oct;24(4):381-5.
doi: 10.1016/j.ijantimicag.2004.03.027.

Influence of thiamphenicol on the primary functions of human polymorphonuclear leucocytes against Streptococcus pyogenes

Vivian Tullio  1 , Annamaria Cuffini, Narcisa Mandras, Janira Roana, Giuliana Banche, Domenico Ungheri, Nicola Carlone
Affiliations

Influence of thiamphenicol on the primary functions of human polymorphonuclear leucocytes against Streptococcus pyogenes

Vivian Tullio et al. Int J Antimicrob Agents. 2004 Oct.

Abstract

Current antibiotic therapy encourages the use of antibiotics that may potentiate the host's immune defences. We therefore investigated the effect of thiamphenicol (TAP), the active principle of thiamphenicol glycinate acetylcysteinate (TGA), on human granulocyte functions, mainly phagocytosis and intracellular killing of Streptococcus pyogenes. Our findings support the use of thiamphenicol in the treatment of respiratory tract infections caused by S. pyogenes as it acts directly against the pathogen as well as in cooperation with PMNs by eliciting their intracellular killing.

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