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. 2004 Sep;6(3):251-61.
doi: 10.1016/j.ccr.2004.07.012.

Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

Shao-Chun Wang  1 , Huang-Chun Lien, Weiya Xia, I-Fen Chen, Hui-Wen Lo, Zhiqin Wang, Mohamed Ali-Seyed, Dung-Fang Lee, Geoffrey Bartholomeusz, Fu Ou-Yang, Dipak K Giri, Mien-Chie Hung
Affiliations
Free article

Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

Shao-Chun Wang et al. Cancer Cell. 2004 Sep.
Free article

Abstract

Pathological expression of human ErbB-2 protein, also known as HER-2, is common in many types of cancer. ErbB-2 is a member of the EGF receptor tyrosine kinase family and has been rigorously studied as a signaling molecule on the cell membrane. Here, we report that ErbB-2 is also expressed in the nucleus in cultured cells as well as primary tumor tissues. Nuclear ErbB-2 was found to associate with multiple genomic targets in vivo, including the cyclooxygenase enzyme COX-2 gene promoter. ErbB-2 forms a complex at a specific nucleotide sequence of the COX-2 promoter and is able to stimulate its transcription. This study demonstrates the presence of ErbB-2 in the nucleus and identifies the function of ErbB-2 as a transcriptional regulator.

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