Review
doi: 10.1016/j.micinf.2004.05.024.
Requirements for Th1-dependent immunity against infection with Leishmania major
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- PMID: 15380780
- DOI: 10.1016/j.micinf.2004.05.024
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Review
Requirements for Th1-dependent immunity against infection with Leishmania major
Microbes Infect.
2004 Oct.
Free article
Abstract
Protective immunity against cutaneous leishmaniasis is dependent on the induction of Th1/Tc1 immune responses resulting in efficient parasite elimination. In this review, the mechanisms leading to protection are discussed with special focus on the role of Leishmania major-infected dendritic cells (DC) in induction of Th1-dependent immunity. Murine strain-dependent differences between DC derived from Leishmania-susceptible as compared to resistant mice are highlighted.
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