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Review
. 2004 Oct;6(12):1102-9.
doi: 10.1016/j.micinf.2004.05.024.

Requirements for Th1-dependent immunity against infection with Leishmania major

Esther von Stebut  1 , Mark C Udey
Affiliations
Free article
Review

Requirements for Th1-dependent immunity against infection with Leishmania major

Esther von Stebut et al. Microbes Infect. 2004 Oct.
Free article

Abstract

Protective immunity against cutaneous leishmaniasis is dependent on the induction of Th1/Tc1 immune responses resulting in efficient parasite elimination. In this review, the mechanisms leading to protection are discussed with special focus on the role of Leishmania major-infected dendritic cells (DC) in induction of Th1-dependent immunity. Murine strain-dependent differences between DC derived from Leishmania-susceptible as compared to resistant mice are highlighted.

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