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Comparative Study
. 2004 Jul;59(1):133-41.
doi: 10.1007/s00239-003-2572-9.

Independent origins of subgroup Bl + B2 and subgroup B3 metallo-beta-lactamases

Barry G Hall  1 , Stephen J Salipante, Miriam Barlow
Affiliations
Comparative Study

Independent origins of subgroup Bl + B2 and subgroup B3 metallo-beta-lactamases

Barry G Hall et al. J Mol Evol. 2004 Jul.

Abstract

The metallo-beta-lactamases constitute Class B in the Ambler classification of beta-lactamases and are divided into three subclasses: Bl, B2, and B3. Bayesian phylogenies of the Subclass B1 + B2 and Subclass B3 metallo-beta-lactamases and their homologs show that the beta-lactam-hydrolyzing function evolved independently within each group. In Subclass B1+B2 that function evolved about 1 billion years ago, and in Subclass B3 it evolved before the divergence of the Gram-positive and Gram-negative eubacteria, about 2 billion years ago. These results lend additional support to the proposal that the metallo-beta-lactamases should be divided into two distinct classes.

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