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. 2004 Sep;70(9):869-70.
doi: 10.1055/s-2004-827238.

A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme

Eun Young Bae  1 , Hyuncheol Oh, Won Keun Oh, Min Soo Kim, Beom Seok Kim, Bo Yeon Kim, Cheon Bae Sohn, Hiroyuki Osada, Jong Seog Ahn
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A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme

Eun Young Bae et al. Planta Med. 2004 Sep.

Abstract

Bioassay-guided fractionation of the EtOAc-soluble extract of Dendrobium moniliforme afforded a new phenanthraquinone-type metabolite, 7-hydroxy-5,6-dimethoxy-1,4-phenanthrenequinone ( 1), along with the previously reported 5-hydroxy-3,7-dimethoxy-1,4-phenanthrenequinone ( 2). The structures of the compounds were identified mainly on the basis of MS and NMR data. Compound 1 inhibited VHR dual-specificity protein tyrosine phosphatase (DS-PTPase) activity in a dose-dependent manner, displaying an IC (50) value of 3.0 +/- 0.2 microM.

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