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. 2004 Oct 1;69(20):6913-5.
doi: 10.1021/jo0489768.

Difluorophenylsulfanylmethyl radical and difluoromethylene diradical synthons: gem-difluoromethylene building block

Vichai Reutrakul  1 , Thanchanok Thongpaisanwong, Patoomratana Tuchinda, Chutima Kuhakarn, Manat Pohmakotr
Affiliations

Difluorophenylsulfanylmethyl radical and difluoromethylene diradical synthons: gem-difluoromethylene building block

Vichai Reutrakul et al. J Org Chem. .

Abstract

Bromodifluorophenylsulfanylmethane has been demonstrated to be a highly versatile gem-difluoromethylene (CF2) building block via the reaction of difluorophenylsulfanylmethyl radical with olefins. gem-Difluoroalkenes and products containing a midchain CF2 group and with manipulatable functionality can be readily synthesized. The first example of a gem-difluoromethylene radical synthon is also reported.

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