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Comparative Study
. 2004 Oct;48(10):4027-32.
doi: 10.1128/AAC.48.10.4027-4032.2004.

Antipneumococcal activity of LBM415, a new peptide deformylase inhibitor, compared with those of other agents

Lois M Ednie  1 , Glenn Pankuch, Peter C Appelbaum
Affiliations
Comparative Study

Antipneumococcal activity of LBM415, a new peptide deformylase inhibitor, compared with those of other agents

Lois M Ednie et al. Antimicrob Agents Chemother. 2004 Oct.

Abstract

The MICs of LBM415, a new peptide diformylase inhibitor, were evaluated and ranged from 0.03 to 4.0 microg/ml for 300 pneumococci, irrespective of their beta-lactam, macrolide, and quinolone susceptibilities. By comparison, vancomycin, teicoplanin, linezolid, and quinupristin-dalfopristin were also active, with MICs </=2.0 microg/ml. Gatifloxacin and moxifloxacin were the most active quinolones tested, while the MICs of the beta-lactams rose with those of penicillin G. LBM415 at two times the MIC was bactericidal (99.9% killing) against six strains after 24 h.

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References

    1. Anderegg, T. R., D. J. Biedenbach, R. N. Jones, and the Quality Control Working Group. 2003. Quality control guidelines for MIC susceptibility testing of NVP-PDF713, a novel peptide deformylase inhibitor. Int. J. Antimicrob. Agents 22:84-86. - PubMed
    1. Anderegg, T. R., R. N. Jones, and the Quality Control Working Group. 2004. Disk diffusion quality control guidelines for NVP-PDF 713: a novel peptide deformylase inhibitor. Diagn. Microbiol. Infect. Dis. 48:55-57. - PubMed
    1. Appelbaum, P. C. 1992. Antimicrobial resistance in Streptococcus pneumoniae—an overview. Clin. Infect. Dis. 15:77-83. - PubMed
    1. Cercenado, E., F. Garcia-Garrote, and E. Bouza. 2001. In-vitro activity of linezolid against multiply resistant gram-positive clinical isolates. J. Antimicrob. Chemother. 47:77-81. - PubMed
    1. Diekema, D. J., and R. N. Jones. 2000. Oxazolidinones. A review. Drugs 59:7-16. - PubMed

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