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. 1979 Jan;63(1):151-3.
doi: 10.1172/JCI109270.

The cellular basis of the impaired autologous mixed lymphocyte reaction in patients with systemic lupus erythematosus

M M Kuntz, J B Innes, M E Weksler

The cellular basis of the impaired autologous mixed lymphocyte reaction in patients with systemic lupus erythematosus

M M Kuntz et al. J Clin Invest. 1979 Jan.

Abstract

The autologous mixed lymphocyte reaction is impaired in patients with systemic lupus erythematosus. This is because nonthymus-derived (T)-lymphocyte preparations from such patients do not stimulate autologous T-lymphocyte proliferation normally. This defect may explain the impaired generation of suppressor activity in systemic lupus erythematosus and thereby the occurrence of autoantibodies in this disease.

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References

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