Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1949 Dec;90(6):543-53.
doi: 10.1084/jem.90.6.543.

The inhibition of streptococcal desoxyribonuclease by rabbit and human antisera

M McCARTY

The inhibition of streptococcal desoxyribonuclease by rabbit and human antisera

M McCARTY. J Exp Med. 1949 Dec.

Abstract

Rabbit antisera against partially purified streptococcal desoxyribonuclease inhibit the action of the enzyme on its substrate. The activity of pancreatic desoxyribonuclease is not affected by these antisera. Similarly antibody against pancreatic nuclease does not inhibit the streptococcal enzyme. Certain patients develop inhibitory antibody to streptococcal desoxyribonuclease following streptococcal infections, occasionally in very high titer, although the proportion of patients showing an antibody response appears to be lower than in the case of streptokinase and streptolysin O. The pattern of antibody response to desoxyribonuclease has been compared to that of streptokinase and streptolysin O in a group of ninety patients from an epidemic of scarlet fever.

PubMed Disclaimer

References

    1. J Clin Invest. 1948 Jul;27(4):425-34 - PubMed
    1. J Exp Med. 1948 Aug;88(2):181-8 - PubMed
    1. J Exp Med. 1948 Dec;88(6):569-77 - PubMed
    1. Proc Natl Acad Sci U S A. 1942 Sep;28(9):344-52 - PubMed
    1. J Infect Dis. 1949 May-Jun;84(3):240-51 - PubMed