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Case Reports
. 1978 Oct;15(5):395-8.
doi: 10.1136/jmg.15.5.395.

Trisomy 21 with 47,+18 lymphocyte cell line: double mitotic nondisjunction

M B Jenkins, R L Kriel, L Boyd, A Barnwell
Case Reports

Trisomy 21 with 47,+18 lymphocyte cell line: double mitotic nondisjunction

M B Jenkins et al. J Med Genet. 1978 Oct.

Abstract

A patient with Down's syndrome was found to have 47,XX,+18/47,XX,+21 mosaicism. Chromosome 18 trisomy was found only in 18% of lymphocytes and not in skin fibroblasts. A likely interpretation is double nondisjunction in a single lymphocyte precursor of a trisomy 21 embryo. A brief review of other cases of mitotic multiple nondisjunction and double aneuploid mosiacism is presented.

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