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. 1992 Jan;61(1):235-45.
doi: 10.1016/S0006-3495(92)81830-1.

Determination of rate distributions from kinetic experiments

P J Steinbach  1 , K Chu, H Frauenfelder, J B Johnson, D C Lamb, G U Nienhaus, T B Sauke, R D Young
Affiliations

Determination of rate distributions from kinetic experiments

P J Steinbach et al. Biophys J. 1992 Jan.

Abstract

Rate processes in proteins are often not adequately described by simple exponential kinetics. Instead of modeling the kinetics in the time domain, it can be advantageous to perform a numerical inversion leading to a rate distribution function f(lambda). The features observed in f(lambda) (number, positions, and shapes of peaks) can then be interpreted. We discuss different numerical techniques for obtaining rate distribution functions, with special emphasis on the maximum entropy method. Examples are given for the application of these techniques to flash photolysis data of heme proteins.

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References

    1. Science. 1976 Jun 4;192(4243):1002-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Oct;80(20):6239-43 - PubMed
    1. Eur J Biochem. 1991 Mar 28;196(3):591-8 - PubMed
    1. Biochemistry. 1991 Apr 23;30(16):3988-4001 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Nov;85(22):8492-6 - PubMed

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