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. 1992 Jan;28(1):127-31.
doi: 10.1016/0361-9230(92)90239-t.

Racemized D-aspartate in Alzheimer neurofibrillary tangles

G H Fisher  1 , I L Payan, S J Chou, E H Man, S Cerwinski, T Martin, C Emory, W H Frey 2nd
Affiliations

Racemized D-aspartate in Alzheimer neurofibrillary tangles

G H Fisher et al. Brain Res Bull. 1992 Jan.

Abstract

Normal protein-bound L-aspartyl/L-asparaginyl residues may undergo posttranslational modification by racemization to D-aspartate. Based on preliminary results reported here, proteins associated with Alzheimer neurofibrillary tangle preparations contain a greater number of these racemized D-aspartyl residues than the unaffected proteins from the surrounding gray matter or in comparable preparations from normal brains.

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