Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1950 Jan 20;33(3):215-28.
doi: 10.1085/jgp.33.3.215.

The ultraviolet light and photosensitized inactivation of tobacco mosaic virus

G OSTER, A D McLEAN

The ultraviolet light and photosensitized inactivation of tobacco mosaic virus

G OSTER et al. J Gen Physiol. .

Abstract

The quantum yield for the inactivation of tobacco mosaic virus has been determined at 253.7 mmicro and found to be 4.3 x 10(-6). The possible significance of the observed one-hit process of inactivation has been discussed in terms of the kinetics and the rupture of model substances including nucleic acid. The ultraviolet light inactivation, which proceeds independent of oxygen, occurs without change in physicochemical properties, with the possible exception of an enhanced sensitivity to thermal denaturation. The photosensitized inactivation of virus by acriflavine has been found to proceed parallel with the destruction of the dye. The action was found to be dependent upon adsorbed dye, and the inactivation is enhanced by the presence of oxygen.

PubMed Disclaimer

References

    1. Arch Biochem. 1949 Nov;24(1):119-28 - PubMed
    1. Nature. 1948 Dec 25;162(4130):1004 - PubMed
    1. Science. 1935 Jun 28;81(2113):644-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1936 Jan;22(1):19-24 - PubMed
    1. Science. 1936 Jun 26;83(2165):626-7 - PubMed