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. 1992 Feb;130(2):295-304.
doi: 10.1093/genetics/130.2.295.

Analysis of URSG-mediated glucose repression of the GAL1 promoter of Saccharomyces cerevisiae

J S Flick  1 , M Johnston
Affiliations

Analysis of URSG-mediated glucose repression of the GAL1 promoter of Saccharomyces cerevisiae

J S Flick et al. Genetics. 1992 Feb.

Abstract

Repression of GAL1 expression during growth on glucose is mediated in part by cis-acting promoter elements designated URSG. We show that oligonucleotides containing sequences from two regions of URSG confer glucose repression upon a heterologous promoter. Repression caused by URSG is dependent on trans-acting factors of the glucose repression pathway and is independent of orientation or location within a promoter, suggesting that URSG contains binding sites for a glucose-activated repressor protein(s). Genetic analysis identified three apparently novel genes (URR1, URR3 and URR4) that are specifically required for URSG-mediated repression and may encode such repressor proteins. Mutations in the URR genes suppress the defect in URSG derepression caused by a snf1 mutation.

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