Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Feb 25;20(4):879-87.
doi: 10.1093/nar/20.4.879.

Homologies between the contiguous and fragmented rRNAs of the two Plasmodium falciparum extrachromosomal DNAs are limited to core sequences

J E Feagin  1 , E Werner, M J Gardner, D H Williamson, R J Wilson
Affiliations
Free PMC article

Homologies between the contiguous and fragmented rRNAs of the two Plasmodium falciparum extrachromosomal DNAs are limited to core sequences

J E Feagin et al. Nucleic Acids Res. .
Free PMC article

Abstract

Plasmodium falciparum contains two extrachromosomal DNAs, a 6 kb linear element and a 35 kb circular DNA; both encode rDNA sequences. The 6 kb element rDNAs comprise fragments of both large and small subunit rRNAs. Comparison of these with corresponding rDNA sequences from the 35 kb DNA and E. coli show that sequences conserved between the three are largely confined to highly conserved core regions; in fact, most of the 6 kb rDNA sequences correspond to core regions. Both the 6 kb element and 35 kb rDNAs show less conservation to each other than to E. coli sequences, suggesting that the two extrachromosomal DNAs of P. falciparum are not closely related. The characteristics of the fragmented rRNAs from the 6 kb element suggest they are functional, possibly in mitochondrial ribosomes.

PubMed Disclaimer

References

    1. Nucleic Acids Res. 1988;16 Suppl:r87-173 - PubMed
    1. EMBO J. 1987 Apr;6(4):1063-71 - PubMed
    1. Mol Cell Biol. 1989 Sep;9(9):3614-20 - PubMed
    1. Cell. 1988 Nov 4;55(3):399-411 - PubMed
    1. Mol Biochem Parasitol. 1985 Feb;14(2):199-209 - PubMed

Publication types

Associated data