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. 1992 Mar 1;89(5):1553-6.
doi: 10.1073/pnas.89.5.1553.

Evidence for the participation of endogenous activin A/erythroid differentiation factor in the regulation of erythropoiesis

M Shiozaki  1 , R Sakai, M Tabuchi, T Nakamura, K Sugino, H Sugino, Y Eto
Affiliations

Evidence for the participation of endogenous activin A/erythroid differentiation factor in the regulation of erythropoiesis

M Shiozaki et al. Proc Natl Acad Sci U S A. .

Abstract

Activin A/erythroid differentiation factor (EDF) is a human protein that induces differentiation of a murine erythroleukemia cell (the Friend cell). In this study, we demonstrate that endogenous activin A/EDF activity is present in murine bone marrow and spleen. In addition, this activity is secreted by bone marrow and spleen cells in primary culture. Administration of follistatin (a specific binding protein for activin A/EDF) to mice results in a decrease of erythroid progenitors in the bone marrow and spleen. These findings support the concept that activin A/EDF and follistatin have opposing actions in the regulation of erythropoiesis.

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References

    1. Proc Natl Acad Sci U S A. 1977 Sep;74(9):3879-82 - PubMed
    1. J Cell Physiol. 1974 Apr;83(2):309-20 - PubMed
    1. Biochem Biophys Res Commun. 1989 Dec 29;165(3):1155-61 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Jan;85(1):247-51 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Aug;83(16):5849-53 - PubMed

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