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. 1992 Feb 24;298(2-3):188-90.
doi: 10.1016/0014-5793(92)80053-j.

17O NMR and FT-IR study of the ionization state of peptides in aprotic solvents. Application to Leu-enkephalin

I P Gerothanassis  1 , N Birlirakis, T Karayannis, V Tsikaris, M Sakarellos-Daitsiotis, C Sakarellos, B Vitoux, M Marraud
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Free article

17O NMR and FT-IR study of the ionization state of peptides in aprotic solvents. Application to Leu-enkephalin

I P Gerothanassis et al. FEBS Lett. .
Free article

Abstract

The ionization state of Leu-enkephalin in DMSO and MeCN/DMSO (4/1) solution was studied by the combined use of 17O NMR and FT-IR spectroscopy. After lyophilization of an aqueous solution at nearly neutral pH, Leu-enkephalin essentially exists in the uncharged state in MeCN/DMSO (4/1) solution. In pure DMSO, only 40% of the Leu-enkephalin molecules are in the zwitterionic state under the same conditions.

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