doi: 10.1016/0014-5793(92)80109-t.
Neuronal and glial gamma-aminobutyric acid+ transporters are distinct proteins
Affiliations
- PMID: 1544482
- DOI: 10.1016/0014-5793(92)80109-t
Item in Clipboard
Neuronal and glial gamma-aminobutyric acid+ transporters are distinct proteins
FEBS Lett.
.
Free article
Abstract
In the central nervous system, two subtypes of sodium- and chloride-coupled GABA transporter exist. One is sensitive to ACHC, the other to beta-alanine. They are thought to be of neuronal and glial origin, respectively. GABA transport in membrane vesicles derived from astroglial cells was found to be sodium- and chloride-dependent, electrogenic and much more sensitive to beta-alanine than to ACHC. Immunoblotting with antibodies directed against a variety of sequences of the ACHC-sensitive transporter indicated that none of these epitopes was shared by the glial transporter.
Similar articles
-
Two pharmacologically distinct sodium- and chloride-coupled high-affinity gamma-aminobutyric acid transporters are present in plasma membrane vesicles and reconstituted preparations from rat brain.Proc Natl Acad Sci U S A. 1990 Apr;87(7):2550-4. doi: 10.1073/pnas.87.7.2550. Proc Natl Acad Sci U S A. 1990. PMID: 2108440 Free PMC article.
-
The gamma-aminobutyric acid transporter and its interaction with taurine in the apical membrane of the bovine retinal pigment epithelium.Biochem J. 1992 Apr 15;283 ( Pt 2)(Pt 2):391-7. doi: 10.1042/bj2830391. Biochem J. 1992. PMID: 1575683 Free PMC article.
-
Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated analogs.J Pharmacol Exp Ther. 2002 Aug;302(2):636-44. doi: 10.1124/jpet.102.034819. J Pharmacol Exp Ther. 2002. PMID: 12130726
-
GABA transporter heterogeneity: pharmacology and cellular localization.Neurochem Int. 1996 Oct;29(4):335-56. doi: 10.1016/0197-0186(95)00158-1. Neurochem Int. 1996. PMID: 8939442 Review.
-
GABA and human spermatozoa: characterization and regulation of GABA transport proteins.Acta Physiol Scand Suppl. 1998 Nov;642:1-61. Acta Physiol Scand Suppl. 1998. PMID: 9853022 Review. No abstract available.
Cited by
-
Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons.J Neurosci. 2002 Feb 1;22(3):782-90. doi: 10.1523/JNEUROSCI.22-03-00782.2002. J Neurosci. 2002. PMID: 11826108 Free PMC article.
-
Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease.J Neurosci. 2006 Sep 13;26(37):9365-75. doi: 10.1523/JNEUROSCI.1504-06.2006. J Neurosci. 2006. PMID: 16971520 Free PMC article.
-
GAT-3, a high-affinity GABA plasma membrane transporter, is localized to astrocytic processes, and it is not confined to the vicinity of GABAergic synapses in the cerebral cortex.J Neurosci. 1996 Oct 1;16(19):6255-64. doi: 10.1523/JNEUROSCI.16-19-06255.1996. J Neurosci. 1996. PMID: 8815906 Free PMC article.
-
Pharmacological and biochemical aspects of GABAergic neurotransmission: pathological and neuropsychobiological relationships.Cell Mol Neurobiol. 2004 Dec;24(6):707-28. doi: 10.1007/s10571-004-6913-z. Cell Mol Neurobiol. 2004. PMID: 15672674 Free PMC article. Review.
-
The diagnosis and treatment of disorders of nucleic acid/nucleotide metabolism associated with epilepsy.Acta Epileptol. 2025 Apr 1;7(1):23. doi: 10.1186/s42494-025-00201-x. Acta Epileptol. 2025. PMID: 40217360 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
