Acid suppression and adenocarcinoma of the esophagus: cause or cure?
- PMID: 15447745
- DOI: 10.1111/j.1572-0241.2004.41077.x
Acid suppression and adenocarcinoma of the esophagus: cause or cure?
Abstract
In this issue El-Serag et al. present a retrospective study which shows that patients with Barrett's esophagus and no dysplasia who were prescribed PPIs had a lesser rate of developing dysplasia than patients who were not prescribed PPIs. Acid suppression has been proposed both as a cause and a cure for the "epidemic" of adenocarcinoma of the esophagus, which has been noted in the United States. The article and the current evidence related to acid suppression and adenocarcinoma of the esophagus are reviewed.
Comment on
-
Proton pump inhibitors are associated with reduced incidence of dysplasia in Barrett's esophagus.Am J Gastroenterol. 2004 Oct;99(10):1877-83. doi: 10.1111/j.1572-0241.2004.30228.x. Am J Gastroenterol. 2004. PMID: 15447744
Similar articles
-
The challenges of Barrett's -- suppression, symptoms or surveillance.Best Pract Res Clin Gastroenterol. 2004;18 Suppl:47-53. doi: 10.1016/j.bpg.2004.06.012. Best Pract Res Clin Gastroenterol. 2004. PMID: 15588795 Review.
-
Risk factors, DNA damage, and disease progression in Barrett's esophagus.Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):620-5. doi: 10.1158/1055-9965.EPI-04-0509. Cancer Epidemiol Biomarkers Prev. 2005. PMID: 15767340
-
Differential response to preoperative chemoradiation and surgery in esophageal adenocarcinomas based on presence of Barrett's esophagus and symptomatic gastroesophageal reflux.Ann Thorac Surg. 2005 May;79(5):1716-23. doi: 10.1016/j.athoracsur.2004.10.026. Ann Thorac Surg. 2005. PMID: 15854962
-
Medical treatment of Barrett's esophagus: can it prevent cancer?Surg Oncol Clin N Am. 2009 Jul;18(3):503-8. doi: 10.1016/j.soc.2009.03.006. Surg Oncol Clin N Am. 2009. PMID: 19500739 Review.
-
The value of surveillance and other unresolved issues in the management of Barrett's esophagus.Nat Clin Pract Gastroenterol Hepatol. 2005 Feb;2(2):60-1. doi: 10.1038/ncpgasthep0088. Nat Clin Pract Gastroenterol Hepatol. 2005. PMID: 16265103 No abstract available.
Cited by
-
Barrett's esophagus in Japanese patients: its prevalence, form, and elongation.J Gastroenterol. 2008;43(12):928-34. doi: 10.1007/s00535-008-2261-y. Epub 2008 Dec 24. J Gastroenterol. 2008. PMID: 19107336
-
Chemoprevention in Barrett's esophagus.J Gastrointest Cancer. 2007;38(1):1-9. doi: 10.1007/s12029-007-9006-7. J Gastrointest Cancer. 2007. PMID: 19065715 Review.
-
Barrett's oesophagus: an ideal model to study cancer genetics.Hum Genet. 2009 Aug;126(2):233-46. doi: 10.1007/s00439-009-0665-2. Epub 2009 Apr 14. Hum Genet. 2009. PMID: 19365640 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical