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Comparative Study
. 1992;22(4):717-20.
doi: 10.1016/0360-3016(92)90510-o.

Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9

G E Adams  1 , I J Stratford, H S Edwards, J C Bremner, S Cole
Affiliations
Comparative Study

Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9

G E Adams et al. Int J Radiat Oncol Biol Phys. 1992.

Abstract

Various bioreductive drugs that are potent hypoxic cell cytotoxins can also function as effective potentiators of radiation action when administered in vivo post irradiation. There is evidence that a contributory mechanism to this potentiation is enhanced sensitivity to the bioreductive drugs exhibited by cells that are damaged sublethally by radiation.

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