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Case Reports
. 2004 May 6;122(3):134-5.
doi: 10.1590/s1516-31802004000300012. Epub 2004 Sep 16.

Central retinal vein prethrombosis as an initial manifestation of protein S deficiency

Paulo de Tarso Ponte Pierre-Filho  1 , Alessandra Maria Mont'Alverne Pierre, Maurício Abujamra Nascimento, Ana Maria Marcondes
Affiliations
Case Reports

Central retinal vein prethrombosis as an initial manifestation of protein S deficiency

Paulo de Tarso Ponte Pierre-Filho et al. Sao Paulo Med J. .

Abstract
in English, Portuguese

Context: Retinal vein thrombosis is most common in old people, and is often associated with systemic vascular disease. One of its rare systemic causes is protein S deficiency.

Case report: A case of a 21-year-old woman with retinal vein prethrombosis associated only with protein S deficiency is described. She presented with acutely reduced visual acuity and a central scotoma in her left eye. Warfarin therapy was initiated, and complete improvement in ophthalmoscopic findings was subsequently observed. This case illustrates that protein S deficiency is a factor that should be considered in cases of retinal vein occlusion, particularly in young patients.

CONTEXTO:: Trombose venosa retiniana é mais comum em pessoas idosas e freqüentemente está associada com doença vascular sistêmica. Uma causa sistêmica rara é a deficiência de proteína S.

RELATO DE CASO:: Um caso de paciente branca, de 21 anos, com pré-trombose de veia central da retina associada à deficiência isolada de proteína S é descrito. Ela apresentou súbito embaçamento visual e escotoma central em olho esquerdo. Terapia cumarínica foi iniciada e completa remissão dos achados oftalmoscópicos foi observada. Este caso mostra que deficiência de proteína S deve ser um fator que deve ser considerado em casos de oclusão venosa retiniana, particularmente em pacientes jovens.

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Conflict of interest statement

Conflict of interest: None

Figures

Figure 1
Figure 1. Bottom: Photograph showing rare dot and blot hemorrhages and blurring of optic disc in the left eye. The optic disc, macula, and retinal vessels appear normal in the right eye. Top: Fluorescein angiogram showing late optic disc hyperfluorescence; the disc is extremely edematous on the left.
See this image and copyright information in PMC

References

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