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Review
. 2004 Oct 1;119(1):3-4.
doi: 10.1016/j.cell.2004.09.023.

The power of pumping together; deconstructing the engine of a DNA replication machine

Brandt F Eichman  1 , Ellen Fanning
Affiliations
Free article
Review

The power of pumping together; deconstructing the engine of a DNA replication machine

Brandt F Eichman et al. Cell. .
Free article

Abstract

The replicative DNA helicase lies at the heart of the eukaryotic replication machine, yet how it works remains puzzling. New structures of the viral replicative helicase SV40 T antigen suggest that a novel concerted mode of nucleotide binding and hydrolysis powers conformation changes and DNA unwinding.

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