The power of pumping together; deconstructing the engine of a DNA replication machine
- PMID: 15454074
- DOI: 10.1016/j.cell.2004.09.023
The power of pumping together; deconstructing the engine of a DNA replication machine
Abstract
The replicative DNA helicase lies at the heart of the eukaryotic replication machine, yet how it works remains puzzling. New structures of the viral replicative helicase SV40 T antigen suggest that a novel concerted mode of nucleotide binding and hydrolysis powers conformation changes and DNA unwinding.
Comment on
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Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen.Cell. 2004 Oct 1;119(1):47-60. doi: 10.1016/j.cell.2004.09.017. Cell. 2004. PMID: 15454080
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