[Physiological effects of C-peptide]

Abstract

Connecting peptide (C-peptide) is a product of proinsulin cleavage. New findings demonstrate, that it may serve to understand the mechanisms involved in the development of long-term complications in type 1 diabetic patients. The present review focuses on: 1. Making a point about C-peptide-induced tubular effects on the basis of clinical and experimental experiments, 2. Precising the molecular mechanisms involved in C-peptide-induced tubular Na,K-ATPase effects.