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Review
. 2004 Sep 29;24(39):8399-403.
doi: 10.1523/JNEUROSCI.3606-04.2004.

Activity-dependent regulation of calcium/calmodulin-dependent protein kinase II localization

Howard Schulman  1
Affiliations
Review

Activity-dependent regulation of calcium/calmodulin-dependent protein kinase II localization

Howard Schulman. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Basis for stimulus-dependent translocation of CaMKII. Schematic representation of target binding site (T site) and substrate binding site (S site) that are blocked by the autoinhibitory gate but are exposed by the displacement of the gate by Ca2+/calmodulin to allow binding to targets such as the distal site of NR2B. Further displacement of the gate after autophosphorylation is necessary for proper binding of other targets, such as L-type Ca2+ channel (LTCC). After dissociation of Ca2+/calmodulin, the former interaction produces an autonomously active kinase, whereas the latter deactivates but remains Ca2+/calmodulin responsive.
See this image and copyright information in PMC

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