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Review
. 2004 Sep 29;24(39):8399-403.
doi: 10.1523/JNEUROSCI.3606-04.2004.

Activity-dependent regulation of calcium/calmodulin-dependent protein kinase II localization

Howard Schulman  1
Affiliations
Review

Activity-dependent regulation of calcium/calmodulin-dependent protein kinase II localization

Howard Schulman. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Basis for stimulus-dependent translocation of CaMKII. Schematic representation of target binding site (T site) and substrate binding site (S site) that are blocked by the autoinhibitory gate but are exposed by the displacement of the gate by Ca2+/calmodulin to allow binding to targets such as the distal site of NR2B. Further displacement of the gate after autophosphorylation is necessary for proper binding of other targets, such as L-type Ca2+ channel (LTCC). After dissociation of Ca2+/calmodulin, the former interaction produces an autonomously active kinase, whereas the latter deactivates but remains Ca2+/calmodulin responsive.
See this image and copyright information in PMC

References

    1. Allbritton NL, Meyer T, Stryer L (1992) Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate. Science 258: 1812-1815. - PubMed
    1. Atkins CM, Nozaki N, Shigeri Y, Soderling TR (2004) Cytoplasmic polyadenylation element binding protein-dependent protein synthesis is regulated by calcium/calmodulin-dependent protein kinase II. J Neurosci 24: 5193-5201. - PMC - PubMed
    1. Bauman AL, Goehring AS, Scott JD (2004) Orchestration of synaptic plasticity through AKAP signaling complexes. Neuropharmacology 46: 299-310. - PubMed
    1. Bayer KU, Schulman H (2001) Regulation of signal transduction by protein targeting: the case for CaMKII. Biochem Biophys Res Commun 289: 917-923. - PubMed
    1. Bayer KU, Lohler J, Harbers K (1996) An alternative, nonkinase product of the brain-specifically expressed Ca2+/calmodulin-dependent kinase II alpha isoform gene in skeletal muscle. Mol Cell Biol 16: 29-36. - PMC - PubMed

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