Review
doi: 10.1038/nrm1491.
Connecting proliferation and apoptosis in development and disease
Affiliations
- PMID: 15459661
- DOI: 10.1038/nrm1491
Item in Clipboard
Review
Connecting proliferation and apoptosis in development and disease
Nat Rev Mol Cell Biol.
2004 Oct.
Abstract
Cells grow and divide rapidly during embryonic and postnatal development. Net tissue growth reflects the balance between the addition of new cells and the elimination of existing cells by programmed cell death. Cells compete for growth and survival factors to ensure an appropriate balance between the addition and elimination of cells. Elaborate mechanisms ensure that cells do not evade these constraints, and thereby prevent uncontrolled proliferation.
Similar articles
-
Antagonism of Myc functions by Arf.Cancer Cell. 2004 Oct;6(4):309-11. doi: 10.1016/j.ccr.2004.09.020. Cancer Cell. 2004. PMID: 15488753
-
Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis.Mol Cell Biol. 2001 Nov;21(22):7653-62. doi: 10.1128/MCB.21.22.7653-7662.2001. Mol Cell Biol. 2001. PMID: 11604501 Free PMC article.
-
Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3.Mol Endocrinol. 1996 Dec;10(12):1688-96. doi: 10.1210/mend.10.12.8961277. Mol Endocrinol. 1996. PMID: 8961277
-
Molecular interaction map of the p53 and Mdm2 logic elements, which control the Off-On switch of p53 in response to DNA damage.Biochem Biophys Res Commun. 2005 Jun 10;331(3):816-27. doi: 10.1016/j.bbrc.2005.03.186. Biochem Biophys Res Commun. 2005. PMID: 15865937 Review.
-
Mdm2 in the response to radiation.Mol Cancer Res. 2004 Jan;2(1):9-19. Mol Cancer Res. 2004. PMID: 14757841 Review.
Cited by
-
Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device.Cell Cycle. 2015;14(2):189-99. doi: 10.4161/15384101.2014.973743. Cell Cycle. 2015. PMID: 25607644 Free PMC article.
-
Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila.EMBO J. 2007 Apr 4;26(7):1772-81. doi: 10.1038/sj.emboj.7601630. Epub 2007 Mar 8. EMBO J. 2007. PMID: 17347649 Free PMC article.
-
HLA-DR alpha 2 mediates negative signalling via binding to Tirc7 leading to anti-inflammatory and apoptotic effects in lymphocytes in vitro and in vivo.PLoS One. 2008 Feb 13;3(2):e1576. doi: 10.1371/journal.pone.0001576. PLoS One. 2008. PMID: 18270567 Free PMC article.
-
Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis.Commun Biol. 2020 Apr 7;3(1):170. doi: 10.1038/s42003-020-0889-1. Commun Biol. 2020. PMID: 32265497 Free PMC article.
-
Intrinsic apoptosis is evolutionarily divergent among metazoans.Evol Lett. 2023 Nov 16;8(2):267-282. doi: 10.1093/evlett/qrad057. eCollection 2024 Apr. Evol Lett. 2023. PMID: 38525035 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
