[Study on serum oxidized low density lipoprotein and anti-oxidized competence in patient with coronary heart disease]

Abstract

Objective: To analyze the serum oxidized low density lipoprotein (OX-LDL) and anti-oxidized competence in patients with coronary heart disease, and to explore the correlation between OX-LDL and atherosclerosis (AS).

Methods: The samples of fasting blood-serum were collected from 50 patients with coronary heart disease (CHD) and 50 normal controls with no cardiovascular disease, diabetes mellitus and nephrosis. The levels of triglyceride (TG), cholesterol (Chol), high density lipoprotein cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), apoproteinA1 (Apo A1), apoproteinB100 (Apo B100), lipoprotein a (Lpa), OX-LDL, lipid oxidation (LPO) and anti-oxidized competence (AOC) were detected.

Results: The levels of TG, Chol, HDL-C, LDL-C, Apo B100 and NO were no difference between the patient with CHD and the normal controls (P>0.05). Lpa, OX-LDL and LPO were significantly higher than those of controls (P<0.05). ApoA1 and AOC were significantly lower than those of controls (P<0.01).

Conclusion: There were no differences in respect to TG, Chol, HDL, LDL, Apo B100 between the CHD patients and normals, but OX-LDL was significantly higher than that of controls (P<0.05) and AOC was significantly lower than that of controls. These data suggest that OX-LDL and AOC promise to find applications as more sensitive and valid markers for evaluating CHD.