The status of Leishmania tarentolae/Trypanosoma platydactyli

Abstract

Taxonomic studies and classification of Leishmania species have developed rapidly in recent years, but controversy still surrounds the relationships between those species infecting lizards and those infecting mammals. Some authorities maintain that the leishmanias o f lizards form a sufficiently distinct group to be ranked as a separate genus - Sauroleishmania(1,2) - while Wallbanks et al. have gone further to suggest that such species might be classified within the genus Trypanosoma(3). This suggestion followed from work showing that promostigote forms of Trypanosoma platydactyli from a gecko, had similar isoenzyme profiles to Leishmania tarentolae, a well-known species from lizards. In this article however, Larry Simpson and George Holz Jr discuss conflicting evidence, concluding from recent studies of DNA and lipid composition that the lizard leishmanias are more closely related to mammalian leishmanias than to trypanosomes.0.