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. 2004 Oct;27(10):1576-9.
doi: 10.1248/bpb.27.1576.

Antimicrobial activity of some pentacyclic triterpenes and their synthesized 3-O-lipophilic chains

Uppuluri Venkata Mallavadhani  1 , Anita Mahapatra, Kaiser Jamil, Peddi Srinivasa Reddy
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Free article

Antimicrobial activity of some pentacyclic triterpenes and their synthesized 3-O-lipophilic chains

Uppuluri Venkata Mallavadhani et al. Biol Pharm Bull. 2004 Oct.
Free article

Abstract

The major metabolites of Diopsyros melanoxylon viz. amyrins and ursolic acid and their lipophilic 3-O-fatty acid ester chains (C12-C18), which are synthesized now under mild esterification conditions in excellent yields (80-95%), were evaluated for their antimicrobial activity against a series of Gram positive and Gram negative bacteria. Significantly these compounds were found to exhibit potent activity against Gram negative bacteria Pseudomonas syringae (ATCC #13457) and fairly good activity against Gram positive bacteria, Bacillus sphaericus (ATCC #14577) and Bacillus subtilis (ATCC #6051).

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