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. 2004 Nov;54(5):932-5.
doi: 10.1093/jac/dkh446. Epub 2004 Oct 7.

Identification of a chromosome-borne class C beta-lactamase from Erwinia rhapontici

Thierry Naas  1 , Daniel Aubert, Sophie Vimont, Patrice Nordmann
Affiliations

Identification of a chromosome-borne class C beta-lactamase from Erwinia rhapontici

Thierry Naas et al. J Antimicrob Chemother. 2004 Nov.

Abstract

Objectives: To characterize the beta-lactamase gene content of Erwinia rhapontici.

Methods: The beta-lactamase gene was cloned, sequenced and expressed in Escherichia coli.

Results: The cloned gene conferred a resistance pattern of an Ambler class C beta-lactamase in E. coli. The AmpC-type enzyme had a pI value of 8.6 and shared 62% amino acid sequence identity with that of Escherichia fergusonii. The ampC gene was associated with a regulatory ampR gene and beta-lactamase production was inducible.

Conclusions: This work provides further evidence of the molecular heterogeneity of beta-lactamases in Erwinia spp. and that plant-pathogenic enterobacterial species may constitute a reservoir of antibiotic resistance genes.

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