Cortical development deNUDEd
- PMID: 15473958
- DOI: 10.1016/j.neuron.2004.10.002
Cortical development deNUDEd
Abstract
The development of the cerebral cortex is a highly orchestrated process of cell division and migration. In this issue of Neuron, Feng and Walsh and Shu et al. examine the roles of two related proteins, Nde1 (mNudE) and Ndel1 (NUDEL), in cortical development. These proteins play a crucial role in centrosome positioning, with Nde1 functioning mainly during progenitor cell divisions and Ndel1 functioning in neuronal migration.
Comment on
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Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning.Neuron. 2004 Oct 14;44(2):263-77. doi: 10.1016/j.neuron.2004.09.030. Neuron. 2004. PMID: 15473966
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Mitotic spindle regulation by Nde1 controls cerebral cortical size.Neuron. 2004 Oct 14;44(2):279-93. doi: 10.1016/j.neuron.2004.09.023. Neuron. 2004. PMID: 15473967
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