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Review
. 2004 Dec;75(6):933-47.
doi: 10.1086/426001. Epub 2004 Oct 11.

Complex genetics of amyotrophic lateral sclerosis

Catherine B Kunst  1
Affiliations
Review

Complex genetics of amyotrophic lateral sclerosis

Catherine B Kunst. Am J Hum Genet. 2004 Dec.
No abstract available

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Figures

Figure 1
Figure 1
Therapeutic approaches utilized in the mutant SOD1 trangenic mice. A variety of therapeutic genes and agents have been tested in the mutant SOD1 transgenic mice. Treatments discussed in the text are in boldface type. The asterisk (*) reflects a result that was observed in G93A but not G85R SOD1 mice.
See this image and copyright information in PMC

References

Electronic-Database Information

    1. alsod.org: The ALS Online Database, http://www.alsod.org/
    1. ALS Therapy Development Foundation, http://www.als.net/
    1. ALS Therapy Development Foundation Treatment Targets, http://www.als.net/research/treatments/targetClasses.asp
    1. Motor Syndromes, http://www.neuro.wustl.edu/neuromuscular/motor.html
    1. Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/Omim/ (for ALS1, SOD1, CCS, EAAT2, GFAP, GLAST, EAAC1, ALS4, ALS2, ALS5, alsin, SETX, ALS-FTD, MAPT, FTD, progressive motor neuron disease without sensory symptoms, DCTN1, GluR2, ADAR2, NF-H, VEGF, SMN1, SMA, SMN2, CNTF, ApoE, GDNF, BDNF, IGF-1, ALS3, ALS6, ALS7, ALS8, VAPB, and ALS X)

References

    1. Abalkhail H, Mitchell J, Habgood J, Orrell R, de Belleroche J (2003) A new familial amyotrophic lateral sclerosis locus on chromosome 16q12.1-16q12.2. Am J Hum Genet 73:383–389 - PMC - PubMed
    1. Al-Chalabi A, Andersen PM, Chioza B, Shaw C, Sham PC, Robberecht W, Matthijs G, Camu W, Marklund SL, Forsgren L, Rouleau G, Laing NG, Hurse PV, Siddique T, Leigh PN, Powell JF (1998) Recessive amyotrophic lateral sclerosis families with the D90A SOD1 mutation share a common founder: evidence for a linked protective factor. Hum Mol Genet 7:2045–205010.1093/hmg/7.13.2045 - DOI - PubMed
    1. Al-Chalabi A, Andersen PM, Nilsson P, Chioza B, Andersson JL, Russ C, Shaw CE, Powell JF, Leigh PN (1999) Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis. Hum Mol Genet 8:157–16410.1093/hmg/8.2.157 - DOI - PubMed
    1. Andersen PM, Nilsson P, Keranen M-L, Forsgren L, Hagglund J, Karlsborg M, Ronnevi L-O, Gredal O, Marklunk SL (1997) Phenotypic heterogeneity in motor neuron disease patients with CuZn-superoxide dismutase mutations in Scandinavia. Brain 120:1723–173710.1093/brain/120.10.1723 - DOI - PubMed
    1. Andersen PM, Sims KB, Xin WW, Kiely R, O’Neill G, Ravits J, Pioro E, Harati Y, Brower RD, Levine JS, Heinicke HU, Seltzer W, Boss M, Brown RH Jr (2003) Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes. Amyotroph Lateral Scler Other Motor Neuron Disord 4:62–73 - PubMed

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