Sex effects on heart rate variability in fibromyalgia and Gulf War illness
- PMID: 15478168
- DOI: 10.1002/art.20687
Sex effects on heart rate variability in fibromyalgia and Gulf War illness
Abstract
Objective: To investigate autonomic abnormalities in male and female fibromyalgia (FM) and Gulf War illness (GWI) patients by comparing heart rate variability (HRV) with that of age- and sex-matched healthy controls.
Methods: Subjects included 26 (19 women, 7 men) with FM, 11 (6 men, 5 women) with GWI, and 36 (18 men,18 women) healthy controls. HRV was determined from Holter recordings obtained in the Clinical Research Center. Analysis of variance compared 24-hour, daytime, and nighttime HRV by sex within groups and by group within sex.
Results: In women with FM or GWI, HRV was significantly lower than in men with FM or GWI. HRV was similar in male and female controls. When HRV was compared by group within sex, HRV was significantly decreased in women with FM or GWI and no significant differences were seen for men with these conditions.
Conclusion: Decreased HRV in FM and GWI appears to be sex dependent. Results suggest that different mechanisms may be operative in symptom expression in men and women with this spectrum of illness.
Similar articles
-
Abnormal sympathovagal balance in men with fibromyalgia.J Rheumatol. 2001 Mar;28(3):581-9. J Rheumatol. 2001. PMID: 11296963
-
Correlations between autonomic dysfunction and circadian changes and arrhythmia prevalence in women with fibromyalgia syndrome.Anadolu Kardiyol Derg. 2009 Apr;9(2):110-7. Anadolu Kardiyol Derg. 2009. PMID: 19357052
-
Dysautonomia among patients with fibromyalgia: a noninvasive assessment.J Rheumatol. 2000 Nov;27(11):2660-5. J Rheumatol. 2000. PMID: 11093450
-
Characteristics of heart rate variability in alcohol-dependent subjects and nondependent chronic alcohol users.Alcohol Clin Exp Res. 2014 Jan;38(1):9-26. doi: 10.1111/acer.12270. Epub 2013 Oct 11. Alcohol Clin Exp Res. 2014. PMID: 24117482 Review.
-
Cardiac autonomic dysfunction in Gulf War syndrome: veterans' hearts don't rest at night.Am J Med. 2004 Oct 1;117(7):531-2. doi: 10.1016/j.amjmed.2004.05.009. Am J Med. 2004. PMID: 15464714 Review. No abstract available.
Cited by
-
Dysfunctional neurotransmitter systems in fibromyalgia, their role in central stress circuitry and pharmacological actions on these systems.Pain Res Treat. 2012;2012:741746. doi: 10.1155/2012/741746. Epub 2011 Oct 2. Pain Res Treat. 2012. PMID: 22110944 Free PMC article.
-
Urinary albumin, protein excretion and circadian blood pressure in patients with fibromyalgia.Rheumatol Int. 2013 Sep;33(9):2391-8. doi: 10.1007/s00296-013-2748-6. Epub 2013 Apr 16. Rheumatol Int. 2013. PMID: 23588409
-
Cerebrospinal fluid corticotropin-releasing factor concentration is associated with pain but not fatigue symptoms in patients with fibromyalgia.Neuropsychopharmacology. 2006 Dec;31(12):2776-82. doi: 10.1038/sj.npp.1301200. Epub 2006 Aug 23. Neuropsychopharmacology. 2006. PMID: 16936702 Free PMC article.
-
Pathophysiology of fibromyalgia.Am J Med. 2009 Dec;122(12 Suppl):S22-30. doi: 10.1016/j.amjmed.2009.09.008. Am J Med. 2009. PMID: 19962493 Free PMC article. Review.
-
Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease.Brain Res. 2018 Feb 15;1681:34-43. doi: 10.1016/j.brainres.2017.12.030. Epub 2017 Dec 24. Brain Res. 2018. PMID: 29277710 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
