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Comment
. 2004 Oct 15;119(2):147-8.
doi: 10.1016/j.cell.2004.10.001.

Translation silenced by fused pair of tRNA synthetases

Paul Schimmel  1 , Karla Ewalt
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Translation silenced by fused pair of tRNA synthetases

Paul Schimmel et al. Cell. .
Free article

Abstract

In this issue of Cell, discover gene-specific translational silencing as a novel function of the fused glutamyl- and prolyl-tRNA synthetase (GluProRS). GluProRS is released from a multisynthetase translation complex in response to gamma-interferon and forms a four-protein GAIT complex that silences translation of ceruloplasmin (Cp), a protein linked to the inflammatory response.

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