NOD2 mutations and Crohn's disease: are Paneth cells and their antimicrobial peptides the link?
- PMID: 15479670
- PMCID: PMC1774293
- DOI: 10.1136/gut.2004.043307
NOD2 mutations and Crohn's disease: are Paneth cells and their antimicrobial peptides the link?
Comment on
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NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression.Gut. 2004 Nov;53(11):1658-64. doi: 10.1136/gut.2003.032805. Gut. 2004. PMID: 15479689 Free PMC article.
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References
-
- Cunliffe RN. α-Defensins in the gastrointestinal tract. Mol Immunol 2003;40:463–7. - PubMed
-
- Cunliffe RN, Mahida YR. Expression and regulation of antimicrobial peptides in the gastrointestinal tract. J Leukoc Biol 2004;75:49–58. - PubMed
-
- Ganz T . Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 2003;3:710–20. - PubMed
-
- O’Neil DA, Porter EM, Elewaut D, et al. Expression and regulation of the human b-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol 1999;163:6718–24. - PubMed
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