Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Nov;53(11):1701-9.
doi: 10.1136/gut.2004.052704.

Apoptosis and colorectal cancer

A J M Watson  1
Affiliations
Review

Apoptosis and colorectal cancer

A J M Watson. Gut. 2004 Nov.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
A simplified diagram of the Wnt/APC pathway. DKK, dickkopf-1; DSH, dishevelled; APC, adenomatous polyposis coli; TCF, T cell factor; Eph, ephrin.
Figure 2
Figure 2
The intrinsic, or mitochondrial, pathway (after Danial and Korsmeyer29). See text for details.
Figure 3
Figure 3
The extrinsic, or death receptor, pathway (see text for details).
Figure 4
Figure 4
The chromosomal instability (CIN) pathway (see text for details).
Figure 5
Figure 5
Mitogenic signals are transduced by Ras which inhibits the retinoblastoma (Rb) protein allowing E2F and Myc to promote cell cycle progression. p16INK4a is a tumour suppressor whose mutation permits cyclin D dependent kinase (CDK) to inhibit Rb. High levels of E2F or Myc activates p14ARF and thereby p53 which has multiple outputs. A series of proapoptotic bcl-2 family members are stimulated and via PTEN the antiapoptotic actions of AKT are inhibited. Note that p53 can still respond to DNA damage, and therefore chemotherapy, if the Ras/Rb pathway is disabled.
Figure 6
Figure 6
The microsatellite instability (MSI) pathway (see text for details).
See this image and copyright information in PMC

References

    1. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer 1972;26:239–57. - PMC - PubMed
    1. Potten CS, Loeffler M. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 1990;110:1001–20. - PubMed
    1. Spradling A , Drummond-Barbosa D, Kai T. Stem cells find their niche. Nature 2001;414:98–104. - PubMed
    1. Stappenbeck TS, Mills JC, Gordon JI. Molecular features of adult mouse small intestinal epithelial progenitors. Proc Natl Acad Sci U S A 2003;100:1004–9. - PMC - PubMed
    1. Potten CS, Owen G, Booth D. Intestinal stem cells protect their genome by selective segregation of template DNA strands. J Cell Sci 2002;115 (Pt 11) :2381–8. - PubMed

MeSH terms

Substances