Case Reports
Presumptive trimethoprim-sulfadiazine-related hepatotoxicosis in a dog
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- PMID: 1548170
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Case Reports
Presumptive trimethoprim-sulfadiazine-related hepatotoxicosis in a dog
J Am Vet Med Assoc.
.
Free article
Abstract
Administration of trimethoprim-sulfadiazine in a dog was associated with vomiting, inappetence, and icterus, and high values of alanine transaminase, aspartate transaminase, alkaline phosphatase, gamma-glutamyltransferase, and total bilirubin concentration. The clinical signs and biochemical abnormalities resolved after discontinuation of the treatment. Histologic examination of sections from a liver biopsy specimen revealed moderate, predominantly portal hepatitis with cholestasis.
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