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. 2004 Nov 15;14(22):5551-4.
doi: 10.1016/j.bmcl.2004.08.069.

Macrocyclic ketone analogues of halichondrin B

Wanjun Zheng  1 , Boris M Seletsky, Monica H Palme, Paul J Lydon, Lori A Singer, Charles E Chase, Charles A Lemelin, Yongchun Shen, Heather Davis, Lynda Tremblay, Murray J Towle, Kathleen A Salvato, Bruce F Wels, Kimberley K Aalfs, Yoshito Kishi, Bruce A Littlefield, Melvin J Yu
Affiliations

Macrocyclic ketone analogues of halichondrin B

Wanjun Zheng et al. Bioorg Med Chem Lett. .

Abstract

Structurally simplified macrocyclic ketone analogues of halichondrin B were prepared by total synthesis and found to retain the potent cell growth inhibitory activity in vitro, stability in mouse serum, and in vivo efficacy of the natural product.

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