doi: 10.1016/j.bmcl.2004.08.069.
Macrocyclic ketone analogues of halichondrin B
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- PMID: 15482922
- DOI: 10.1016/j.bmcl.2004.08.069
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Macrocyclic ketone analogues of halichondrin B
Bioorg Med Chem Lett.
.
Abstract
Structurally simplified macrocyclic ketone analogues of halichondrin B were prepared by total synthesis and found to retain the potent cell growth inhibitory activity in vitro, stability in mouse serum, and in vivo efficacy of the natural product.
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