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Comment
. 2004 Oct;21(4):458-60.
doi: 10.1016/j.immuni.2004.10.002.

Retinoic acid: an educational "vitamin elixir" for gut-seeking T cells

J Rodrigo Mora  1 , Ulrich H von Andrian
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Retinoic acid: an educational "vitamin elixir" for gut-seeking T cells

J Rodrigo Mora et al. Immunity. 2004 Oct.
Free article

Abstract

T cell priming by dendritic cells (DC) from gut-associated lymphoid tissues gives rise to effector cells with pronounced gut tropism. The mechanism for DC-dependent imprinting of gut specificity has remained unknown. New findings point to retinoic acid, which is uniquely produced by intestinal DC, but not by DC from other lymphoid organs.

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