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. 2004 Nov;90(11):1269-74.
doi: 10.1136/hrt.2003.026989.

Paradox of circulating advanced glycation end product concentrations in patients with congestive heart failure and after heart transplantation

A Heidland  1 , K Sebeková, A Frangiosa, L S De Santo, M Cirillo, F Rossi, M Cotrufo, A Perna, A Klassen, R Schinzel, N G De Santo
Affiliations

Paradox of circulating advanced glycation end product concentrations in patients with congestive heart failure and after heart transplantation

A Heidland et al. Heart. 2004 Nov.

Abstract

Objectives: To analyse circulating concentrations of advanced glycation end products (AGEs) in patients with severe congestive heart failure (CHF) and after heart transplantation; to identify the potential contribution of kidney function to plasma AGE concentrations; and to determine whether AGE concentrations and parameters of oxidative stress are interrelated.

Methods and results: Circulating N(epsilon)-(carboxymethyl)lysine (CML) and AGE associated fluorescence (AGE-Fl), lipid peroxidation, and glomerular filtration rate (GFR) were measured in a cross sectional study of 22 patients with advanced CHF, 30 heart transplant recipients, and 20 healthy controls. Compared with the controls, the CHF patients had decreased CML (mean (SEM) 467.8 (20.0) ng/ml v 369.3 (22.3) ng/ml, p < 0.01), AGE-Fl (mean (SEM) 302.2 (13.3) arbitrary units v 204.9 (15.7) arbitrary units, p < 0.01), and GFR (p < 0.01). CML was positively related to decreased total protein and serum albumin and negatively to body mass index (p < 0.01). In contrast, in the heart transplant group, impaired GFR was associated with a notable rise of both CML (mean (SEM) 876.1 (53.1) ng/ml, p < 0.01) and AGE-Fl (mean (SEM) 385.6 (26.1) arbitrary units, p < 0.01). A positive relation between CML and serum albumin (r = 0.394, p < 0.05) and lipofuscin (r = 0.651, p < 0.01) was found.

Conclusions: The contrasting concentration of CML and AGE-Fl between patients with CHF and after heart transplantation in the presence of decreased GFR and oxidative stress are explained by lowered plasma proteins in CHF and higher concentrations in heart transplant recipients. In heart transplant recipients, in addition to myocardial inflammatory processes, immunosuppression may be important for enhanced formation of AGEs.

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Figures

Figure 1
Figure 1
Relation between plasma Nɛ-(carboxymethyl)lysine (CML) concentration and body mass index (BMI) in 22 patients with congestive heart failure (CHF).
Figure 2
Figure 2
Relation between plasma malondialdehyde (MDA) and plasma advanced glycation end product associated fluorescence (AGE-Fl) in 22 patients with CHF. AU, arbitrary units.
Figure 3
Figure 3
Relation between CML and albumin concentration in patients with CHF, heart transplant recipients (TX), and controls (CTRL).
Figure 4
Figure 4
Relation between AGE-Fl and albumin concentration in patients with CHF, heart TX recipients, and CTRL.
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References

    1. Brownlee M . Advanced protein glycosylation in diabetes and aging. Annu Rev Med 1995;46:223–34. - PubMed
    1. Schleicher ED, Wagner E, Nerlich AG. Increased accumulation of the glycoxidation product N (epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest 1997;9:457–68. - PMC - PubMed
    1. Šebeková K , Podracká L, Blažíček P, et al. Plasma levels of advanced glycation end products in children with renal disease. Pediatr Nephrol 2001;16:1105–12. - PubMed
    1. Šebeková K , Kupčová V, Schinzel R, et al. Markedly elevated levels of plasma advanced glycation end products in patients with liver cirrhosis: amelioration by liver transplantation. J Hepatol 2002;36:66–71. - PubMed
    1. Miyata T , Wada Y, Cai Z, et al. Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure. Kidney Int 1997;51:1170–81. - PubMed

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