Comparative Study
doi: 10.1023/B:GLYC.0000045097.19353.73.
Synthesis of the Lewis b hexasaccharide and HSA-conjugates thereof
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- PMID: 15486457
- DOI: 10.1023/B:GLYC.0000045097.19353.73
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Comparative Study
Synthesis of the Lewis b hexasaccharide and HSA-conjugates thereof
Glycoconj J.
2004.
Abstract
An efficient and short route has been elaborated for the aminopropyl spacer equipped Leb hexasaccharide. For the preparation of HSA-conjugates of this oligosaccharide, the use of disuccinimidyl suberate (DSS) and disuccinimidyl glutarate (DSG) as cross-linker reagents has been evaluated. This conjugation method emerged as being faster and easier to monitor by standard MALDI-TOF spectrometry than squarate ester based conjugations of similar efficiency if DSS is used as cross-linker.
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