Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Dec;75(6):1143-8.
doi: 10.1086/426405. Epub 2004 Oct 14.

A combined linkage-physical map of the human genome

X Kong  1 , K Murphy, T Raj, C He, P S White, T C Matise
Affiliations

A combined linkage-physical map of the human genome

X Kong et al. Am J Hum Genet. 2004 Dec.

Erratum in

  • Am J Hum Genet. 2005 Feb;76(2):373

Abstract

We have constructed de novo a high-resolution genetic map that includes the largest set, to our knowledge, of polymorphic markers (N=14,759) for which genotype data are publicly available; that combines genotype data from both the Centre d'Etude du Polymorphisme Humain (CEPH) and deCODE pedigrees; that incorporates single-nucleotide polymorphisms; and that also incorporates sequence-based positional information. The position of all markers on our map is corroborated by both genomic sequence and recombination-based data. This specific combination of features maximizes marker inclusion, coverage, and resolution, making this map uniquely suitable as a comprehensive resource for determining genetic map information (order and distances) for any large set of polymorphic markers.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Frequency distribution of the number of informative meioses per marker.
Figure 2
Figure 2
Comparison of map distances on our map of chromosome 3, using only the genotype data from the CEPH pedigrees (dotted line) versus using only the genotype data from the deCODE pedigrees (solid line). Similar graphs for all chromosomes can be viewed on the authors' Web site.
See this image and copyright information in PMC

References

Electronic-Database Information

    1. Authors' Web site, http://compgen.rutgers.edu/maps/ (for Rutgers Linkage-Physical Maps)
    1. Center for Medical Genetics, Marshfield Clinic, http://research.marshfieldclinic.org/genetics/ (for the Marshfield genetic maps)
    1. CEPH Genotype Database, http://www.cephb.fr/cephdb/
    1. dbSNP Home Page, http://www.ncbi.nlm.nih.gov/SNP/
    1. eGenome, http://genome.chop.edu/

References

    1. Bahlo M, Xing L, Wilkinson CR (2004) HumanMSD and MouseMSD: generating genetic maps for human and murine microsatellite markers. Bioinformatics. http://bioinformatics.oupjournals.org/cgi/reprint/bth375v1 (electronically published June 24, 2004; accessed October 12, 2004) - PubMed
    1. Broman KW, Murray JC, Sheffield VC, White RL, Weber JL (1998) Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am J Hum Genet 63:861–869 - PMC - PubMed
    1. Dausset J, Cann H, Cohen D, Lathrop M, Lalouel J-M, White R (1990) Centre d’Etude du Polymorphisme Humain (CEPH): collaborative genetic mapping of the human genome. Genomics 6:575–577 - PubMed
    1. Dib C, Faure S, Fizames C, Samson D, Drouot N, Vignal A, Millasseau P, Marc S, Hazan J, Seboun E, Lathrop M, Gyapay G, Morissette J, Weissenbach J (1996) A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 380:152–15410.1038/380152a0 - DOI - PubMed
    1. Kennedy G, Matsuzaki H, Dong S, Liu W, Huang J, Liu G, Su X, Cao M, Chen W, Zhang J, Liu W, Yang G, Di X, Ryder T, He Z, Surti U, Phillips M, Boyce-Jacino M, Fodor S, Jones K (2003) Large-scale genotyping of complex DNA. Nat Biotechnol 21:1233–123710.1038/nbt869 - DOI - PubMed

Publication types

Substances

LinkOut - more resources