Factors associated with psychosis among patients with severe acute respiratory syndrome: a case-control study
- PMID: 15486852
- PMCID: PMC7107870
- DOI: 10.1086/424016
Factors associated with psychosis among patients with severe acute respiratory syndrome: a case-control study
Abstract
We observed that a number of patients with severe acute respiratory syndrome (SARS) developed affective psychosis during the acute phase of their illness. We reviewed all SARS-related psychiatric consultations in Hong Kong and investigated the risk factors for psychosis among patients with SARS in a matched case-control study. Patients with SARS-related psychosis received higher total doses of steroids and had higher rates of family history of psychiatric illness. The findings of the present study suggest that steroid toxicity, personal vulnerability, and, probably, psychosocial stressors jointly contributed to the development of psychosis in patients with SARS.
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References
-
- Naber D, Sand P, Heigl B. Psychopathological and neuropsychological effects of 8-days' corticosteroid treatment: a prospective study. Psychoneuroendocrinology. 1996;21:25–31. - PubMed
-
- Boston Collaborative Drug Surveillance Program Acute adverse reactions to prednisone in relation to dosage. Clin Pharmacol Ther. 1972;13:694–8. - PubMed
-
- Lau KK, Yu WC, Chu CM, Lau ST, Sheng B, Yuen KY. Possible central nervous system infection by SARS coronavirus. Emerg Infect Dis. 2004;10:342–4. Available at: http://www.cdc.gov/ncidod/EID/vol10no2/03-0638.htm. Accessed 19 February 2004. - PMC - PubMed
-
- First MB, Spitzer RL, Gibbon M, Williams JB. Structured clinical interview for DSM-IV-TR axis I disorders, research version, non-patient edition (SCID-I/NP) New York: Biometrics Research, New York State Psychiatric Institute; 2001.
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